Here are the 55 US AI startups that have raised $100M or more in 2025

The AI industry entered 2025 with strong momentum. There were 49 startups that raised funding rounds worth $100 million or more in 2024, per our count at TechCrunch; three companies raised more than one “mega-round,” and seven companies raised rounds that were $1 billion in size or larger. The industry didn’t slow down in 2025. While less companies raised rounds larger than $1 billion, four — Anthropic raised two rounds over $1 billion — significantly more companies raised multiple rounds compared to 2024, eight. How will 2026 compare? Elon Musk’s xAI announced a $20 billion Series E round and Sam Altman’s brain computer interface startup Merge Labs raised a $250 million seed round (with OpenAI as the lead investor) in the first few weeks of 2026, so signs point to another strong year. Of course, it’s still early; we’ll be watching to see if the momentum continues. Here are all the U.S. AI companies that raised $100 million this year: December: - Austin, Texas-based Mythic, which builds power-efficient compute for AI, raised a $125 million venture round that was led by DCVC. The round was announced on December 17 and included SoftBank, NEA and Linse Capital, among other investors. - Chai Discovery announced a $130 million Series B round on December 15. The round valued the company that builds AI models for biotech and drug discovery at $1.2 billion. Oak HC/FT and General Catalyst co-led the round. - Generative media platform Fal announced its third funding round of 2025 on December 9. This $140 million Series D round was led by Sequoia and valued the company at more than $4.5 billion. - Unconventional AI announced a monster $475 million seed round led by Lightspeed Venture Partners and Andreesen Horowitz on December 8. The round valued the one-year-old startup, which is rethinking the foundation of computers in the age of AI, at nearly $4.5 billion. - Boston-based 7AI, which builds cybersecurity AI agents, raised a $130 million Series A round that was announced on December 4. Index Ventures led the round with participation from Greylock, Spark Capital and CRV, among others. November - All-in-one AI workspace platform Genspark announced a $275 million Series B round that valued the company at $1.25 billion on November 20. The round included Emergence Capital Partners, SBI Investment, and LG Technology Ventures, among others. - Luma AI, which builds models used for photo and video creation, raised $900 million in a Series C round that valued the startup at $4 billion. The round was led by Humain with participation from Andreessen Horowitz, AMD Ventures and Amplify Partners, among others. - Anysphere, the maker of viral vibe-coding platform Cursor, raised $2.3 billion in a funding round that valued the company at $29.3 billion. The round was announced on November 13 and is the company’s second funding round this year. - Parallel, which builds web infrastructure for AI agents, raised a $100 million Series A round that was announced on November 12. The round was co-led by Index Ventures and Kleiner Perkins. - Healthcare AI agent startup Hippocratic AI raised a $126 million Series C round that valued the company at $3.5 billion. The round was the company’s second this year, was announced on November 3, and was led by Avenir Growth. October - Fireworks AI, a platform that allows users to build AI applications using open source models, raised a $250 million Series C round that was announced on October 28. The round valued the company at $4 billion. - Enterprise AI startup Uniphore is valued at $2.5 billion after a $260 million Series F round that was announced on October 22. The round included Snowflake Ventures, Nvidia, Databricks Ventures, and AMD, among others. - Sesame, a voice AI company, raised a $250 million Series B round co-led by Sequoia and Spark Capital. The round was announced on October 21 and also included SignalRank as a participant. - Cambridge, Massachusetts’s based OpenEvidence, which builds an AI chatbot for the medical field, raised its second funding round of 2025. The $200 million Series C round was announced on October 20 and valued the company at $6 billion. - Lila Sciences, which is looking to build a science superintelligence platform, announced its second funding round of 2025 on October 14. The $350 million Series A round was co-led by Braidwell and Collective Global. - DeepSeek competitor Reflection AI announced its second mega-round of the year on October 9. The $2 billion Series B round valued the company at $8 billion and was led by Nvidia. - EvenUp, which builds AI for the personal injury legal field, announced a $150 million Series E round that valued the company at more $2 billion on October 7. The round was led by Bessemer with participation from Lightspeed, Bain Capital and SignalFire, among others. September - Periodic Labs, which is building an AI scientist, announced a $300 million seed round on September 30. Felicis and Andreessen Horowitz led the round with participation from Nvidia, Lightspeed, and Khosla Ventures, among others. - Cerebras Systems, an AI infrastructure company, raised a sizable $1.1 billion Series G round that valued the company at $8.1 billion. The round was announced on September 30 and was co-led by Fidelity and Atreides Management. - Modular announced a $250 million funding round on September 24. The round was led by US Innovative Technology Fund with participation from GV, Greylock, and General Catalyst, among others. - Distyl AI, which builds AI enterprise software, raised a $175 million Series B round that was announced on September 23. This round valued the startup at $1.8 billion and included investors like Khosla Ventures and Lightspeed. - AI infrastructure startup Upscale AI raised a sizable $100 million seed round that was co-led by Maverick Silicon and Mayfield. The round was announced on September 17 and also included StepStone Group, Stanford University, and Qualcomm Ventures, among others. - Groq, an AI inference company, raised a $750 million Series D-3 round that valued the company at nearly $6.9 billion. The round was announced on September 17 and was led by Disruptive. - AI training startup Invisible Technologies was valued at $2 billion after a $100 million fundraise that was announced on September 16. The raise was led by Vanara Capital with participation from Greycroft, Tallwoods Capital, and Freestyle Capital, among others. - Cognition AI, the creator of vibe-coding agent Devin, raised a $400 million Series C round that was announced on September 8. The round was led by Founders Fund and valued the company at $10.2 billion. - AI Infrastructure startup Baseten raised a $150 million Series D round that valued the company at $2.1 billion. The September 5 round was led by Bond with participation from CapitalG, IVP and Spark Capital, among others. - Bret Taylor’s customer service AI agent platform Sierra raised $350 million in a round led by Greenoaks Capital. This fundraise was announced on September 4 and valued Sierra at more than $10 billion. - You.com, a personalized AI search engine, raised a $100 million Series C round led by Cox Enterprises. The round was announced on September 3 and valued the company at $1.5 billion. - AI research lab Anthropic raised its second round of 2025 in September. Anthropic announced a $13 billion Series F round on September 2 that valued the company at $183 billion. The round was led by Iconiq, Fidelity, and Lightspeed. August - Healthcare and housing automation platform EliseAI raised $250 million in a Series E round that valued the startup at $2.2 billion. The round, which was announced on August 20, was led by Andreessen Horowitz. - Decart, an AI research lab, raised $100 million at a $3.1 billion valuation. The round included Sequoia Capital, Benchmark, and Zeev Ventures, among others, and was announced on August 7. July - Generative media platform Fal raised a $125 million Series C round led by Meritech Capital Partners. The company announced the round, which values Fal at $1.5 billion, on July 31. Salesforce Ventures, Shopify Ventures, Google AI Futures Fund, and others joined the round. - Five-year-old Ambience Healthcare, which is building an AI healthcare operating system, raised a $243 million Series C round that was led by Oak HC/FT and Andreessen Horowitz. Kleiner Perkins, OpenAI Startup Fund, Smash Capital, and others also participated in the round. - Reka AI, an AI research lab, raised $110 million in a round that included Snowflake and Nvidia. The Series B round was announced on July 22 and values the company at $1 billion. - AI research lab Thinking Machines Lab confirmed that it raised $2 billion on July 15. This sizable seed round was led by Andreessen Horowitz with participation from Nvidia, Accel, and AMD, among others. The round values the company at $12 billion. - Cambridge, Massachusetts-based OpenEvidence, which is building an AI-powered search tool for clinicians, raised $210 million at a $3.5 billion valuation. The Series B round was announced on July 15 and was led by Kleiner Perkins and GV. - Harmonic, which is building a mathematical reasoning engine, raised a $100 million Series B round led by Kleiner Perkins. The round was announced on July 10 and values the company at $875 million. June - Healthcare AI unicorn Abridge announced it raised a $300 million Series E round that values the company at $5.3 billion. The round was led by Andreessen Horowitz with Khosla Ventures participating. It was the company’s second round of 2025. - Harvey, which builds AI tools for the legal industry, announced it raised its second $300 million round of 2025 on June 23. This latest Series E round was co-led by Kleiner Perkins and Coatue and brings the company’s valuation to $5 billion. - Healthcare AI startup Tennr announced it raised a $101 million Series C round led by IVP with participation from Lightspeed Venture Partners, GV, and Andreessen Horowitz, among others. The round values the company at $605 million. - Enterprise search startup Glean continues to rake in cash. The company announced a $150 million Series F round on June 10, led by Wellington Management with participation from Sequoia, Lightspeed Venture Partners, and Kleiner Perkins, among others. Glean is now valued at $7.25 billion. - Anysphere, the AI research lab behind AI coding tool Cursor, raised a sizable $900 million Series C round that values the company at nearly $10 billion. The round was led by Thrive Capital with participation from Andreessen Horowitz, Accel, and DST Global. May - AI data labeling startup Snorkel AI announced a $100 million Series D round on May 29, valuing the company at $1.3 billion. The round was led by Addition with participation from Prosperity7 Ventures, Lightspeed Venture Partners, and Greylock. - LMArena, a popular, community-driven benchmarking tool for AI models, raised a $100 million seed round that valued the startup at $600 million. The round was announced on May 21 and was co-led by Andreessen Horowitz and UC Investments. Lightspeed Venture Partners, Kleiner Perkins, and Felicis also participated, among others. - Las Vegas-based AI infrastructure company TensorWave announced a $100 million Series A round on May 14. The round was co-led by Magnetar Capital and AMD Ventures with participation from Prosperity7 Ventures, Nexus Venture Partners, and Maverick Silicon. April - SandboxAQ closed a $450 million Series E round on April 4 that valued the AI model company at $5.7 billion. The round included Nvidia, Google, and Bridgewater Associates founder Ray Dalio among other investors. - Runway, which creates AI models for media production, raised a $308 million Series D round that was announced on April 3, valuing the company at $3 billion. It was led by General Atlantic. SoftBank, Nvidia, and Fidelity also participated. March - AI behemoth OpenAI raised a record-breaking $40 billion funding round that valued the startup at $300 billion. This round, which closed on March 31, was led by SoftBank with participation from Thrive Capital, Microsoft, and Coatue, among others. - On March 25, Nexthop AI, an AI infrastructure company, announced that it had raised a Series A round led by Lightspeed Venture Partners. The $110 million round also included Kleiner Perkins, Battery Ventures, and Emergent Ventures, among others. - Cambridge Massachusetts-based Insilico Medicine raised $110 million for its generative AI-powered drug discovery platform as announced on March 13. This Series E round valued the company at $1 billion and was co-led by Value Partners and Pudong Chuangtou. - AI infrastructure company Celestial AI raised a $250 million Series C round that valued the company at $2.5 billion. The March 11 round was led by Fidelity with participation from Tiger Global, BlackRock, and Intel CEO Lip-Bu Tan, among others. - Lila Sciences raised a $200 million seed round as it looks to create a science superintelligence platform. The round was led by Flagship Pioneering. The Cambridge, Massachusetts-based company also received funding from March Capital, General Catalyst, and ARK Venture Fund, among others. - Brooklyn-based Reflection.Ai, which looks to build superintelligent autonomous systems, raised a $130 million Series A round that values the 1-year-old company at $580 million. The round was led by Lightspeed Venture Partners and CRV. - AI coding startup Turing closed a Series E round on March 7 that valued the startup, which partners with LLM companies, at $2.2 billion. The $111 million round was led by Khazanah Nasional with participation from WestBridge Capital, Gaingels, and Sozo Ventures, among others. - Shield AI, an AI defense tech startup, raised $240 million in a Series F round that closed on March 6. This round was co-led by L3Harris Technologies and Hanwha Aerospace, with participation from Andreessen Horowitz and the US Innovative Technology Fund, among others. The round valued the company at $5.3 billion - AI research and large language model company Anthropic raised $3.5 billion in a Series E round that valued the startup at $61.5 billion. The round was announced on March 3 and was led by Lightspeed with participation from Salesforce Ventures, Menlo Ventures, and General Catalyst, among others. February - Together AI, which creates open source generative AI and AI model development infrastructure, raised a $305 million Series B round that valued the company at $3.3 billion. The February 20 round was co-led by Prosperity7 and General Catalyst with participation from Salesforce Ventures, Nvidia, Lux Capital, and others. - AI infrastructure company Lambda raised a $480 million Series D round that was announced on February 19. The round valued the startup at nearly $2.5 billion and was co-led by SGW and Andra Capital. Nvidia, G Squared, ARK Invest, and others also participated. - Abridge, an AI platform that transcribes patient-clinician conversations, was valued at $2.75 billion in a Series D r